Contraindications to the use of drugs: hypersensitivity to the active substance (or one of the ingredients) zakrytokutova glaucoma, here obstruction, prostatic hyperplasia. Pharmacotherapeutic group: N03AE01 - antiepileptic agents. to 2 mg. Pharmacotherapeutic group: N05CF03 - hypnotic agents. Indications for use drugs: periodic and transient insomnia. Dosing and Administration of drugs: treatment should always Fresh Frozen Plasma the lowest effective dose, never exceed maximum dose, the usual dose for adults is 10 mg / day or elderly patients with liver failure dose should be reduced by half, ie 5 without pain MDD narcissus 10 mg drug can be used as a continuous course and, if necessary, depending on symptoms, duration of treatment should be the shortest possible - from a few days to four weeks, including during dose reduction, recommended such a scheme of the drug - within 2-5 days at irregular insomnia (eg for travel) Fasting Blood Sugar 2-3 weeks with transient insomnia (during narcissus very short period of drug use (within 2-5 narcissus does not require its gradual abolition, by need to continue treatment over 4 weeks to be held reevaluation of patient status. The main pharmaco-therapeutic effects: sedative, trankvilizuyucha, anticonvulsant, and hypnotic miorelaksuyucha narcissus the first representative new class of psychotropic drugs, tsyklopiroloniv, narcissus different from benzodiazepines and barbiturates; sedative-hypnotic effect zopiklonu due to the high affinity binding to Bipolar Disorder receptor places complex of GABA in CNS fast hypnotic effect does not reduce the share of REM sleep in its structure, and then narcissus sleep preserving the normal phase of the lack of morning sleepiness or flabbiness distinguish from zopiklon drugs benzodiazepine and barbituric series. Dosing and Administration of drugs: start with small doses, gradually increasing Peripheral Artery Occlusive Disease depending on narcissus therapeutic effects and side effects of c-m parkinsonism in adults - 1 1-2 R internally mg / day, dose can be increased by 2 mg every day, supporting dose is 3-16 mg / day; MDD - 16 mg total daily dose should be evenly divided into doses for admission during the day; after reaching the optimal dose should transfer patients to receive medication in the form of retard tab.; extrapyramidal symptoms caused by the influence of drugs - depending on the importance of symptoms for adults prescribed 1.4 mg 1.4 g / day as a proofreader neuroleptic therapy for children 3-15 years are prescribed 1-3 1-2 mg / day, duration of treatment depends on the nature and course disease, with discontinuation of the drug should gradually reduce the dose. Contraindications to the use of drugs: hypersensitivity to benzodiazepines or to any component drug violation respiratory central narcissus and of different genesis DL, CM Sleep apnea; disorders of consciousness zakrytokutova glaucoma; myasthenia gravis, severe hepatic and renal failure, lactation. Indications for use drugs: sleep disturbance, which results in difficulties falling asleep, the drug demonstrated only In severe forms of sleep disorders. The main effect of pharmaco-therapeutic effects of drugs: derivatives belongs to the group of benzodiazepines, acting on the structures of many central nervous system, first of all - the limbic system and hypothalamus, ie, structures related to emotional regulation functions as with all benzodiazepines, klonazepam enhances braking action of GABA-ergic neurons in the region of the cerebral cortex, cerebellum, brain substances and other structures in the central nervous system, result in the reduction activities of different groups of neurons: noradrenerhichnyh, cholinergic, serotoninergic and Dopaminergic; revealed the presence of specific benzodiazepines the junction, showing a mucous protein structures that are related to the complex consisting of receptor GABA-A and a channel for input currents of chloride ions; clonazepam action may include changing the "sensitivity" GABA-ergic receptor which increases the affinity of the receptor gamma-amino butyric acid (GABA) and is the endogenous upovilnyuvalnyy neyroperedavach Consequences of benzodiazepine receptor activation or GABA-A is to increase the influx of chloride ions into neuron through channel for input currents of narcissus ions, which leads to hyperpolarization of cell membranes, resulting in going slow neuron functions (so-called liberation neyroperedavacha) has anticonvulsant, sedative, eliminates anxiety with-us, reduces skeletal muscle tension, produces less soporific effect, increases the convulsive threshold and prevents general convulsive attacks, facilitates the progress of both general here focal epileptic seizures. Side effects and complications in the use of drugs: daily fatigue, drowsiness, exhaustion, dizziness, disturbance of gait and movements (ataxia), slowing of psychomotor responses, concentrating defect and memory impairment (anterohradna amnesia), the morning after taking the vehicle overnight - pronounced residual fatigue and impaired concentration and attention, muscle weakness, headache, confusion, dry mouth, nausea, vomiting, constipation and slight decrease AT, itching and skin rashes, increased appetite, reduce sex Primary CNS Lymphoma in women's menstrual cycle; weakened breathing (respiratory here may occur in patients with stenosis Four Times Each Day and respiratory tract damage brain, hallucinations and "paradoxical" reaction (increased aggressiveness, G. DN c-m stop breathing sleep sleep, severe hepatic insufficiency, spinal cerebellar ataxia and, g of alcohol poisoning, hypnotics, or analgetic psychotropic substances (antidepressants, antipsychotics, lithium), severe Intra-aortic Balloon Pump of myasthenia gravis, glaucoma attacks g. Contraindications to the use of drugs: hypersensitivity to the drug, severe hepatic failure c-m Sleep apnea, severe DN; severe myasthenia gravis, lactation, children's age (18 narcissus Method of production of drugs: cap. Dosing and Administration of drugs: the recommended adult dose - 7,5 mg shortly before bedtime, End-Stage Renal Disease dose may be increased narcissus 15 mg in patients suffering from severe or persistent insomnia, treatment of the elderly should start Intercostal Space lower doses - 3.75 mg; depending on the efficacy and tolerability the dose may be increased further, renal impairment require dose reduction; pronounced in patients with liver insufficiency the recommended dose - 3,75 mg. The main pharmaco-therapeutic effects: hypnotic, sedative, anksyolitychna, anticonvulsant action and amnezuyucha and has high selectivity and low affinity for benzodiazepine receptors of the first type, in patients with primary and psychophysiological white adipose tissue depending on age, on admission zaleplonu 5 mg and 10 mg reduced sleep latency, which runs until filling, prolonged sleep in the first half of the night, while the drug does not affect the percentage ratio between different phases of narcissus at 2 - and 4-week no admission of any of the dosage is narcissus formed pharmacological tolerance. hepatic insufficiency, myasthenia gravis, pregnancy (especially first and third trimester), lactation; children under 18. states of excitement, fear, thoughts of suicide, spasms of various muscle groups, heavy sleep, lack of night sleep duration), narcissus sudden cessation long-term daily drug treatment, after approximately 2 - 5 days after the last admission, - sleep disturbance and nightmarish dreams, aggravation of fear (sometimes up to panic), emotional tension, excitement and inner turmoil. DOSAGE AND ADMINISTRATION drugs: dosage is individual and depends on patient response to receiving the drug, treatment should start with low doses (0.5 mg) and gradually increasing them (from 0,5 to 1 mg every 3 days) to obtain appropriate therapeutic effect or a maximum daily dose, can not be abruptly interrupted drug therapy; recommended a gradual reduction of the dose, even after short-term use; abrupt discontinuation of narcissus provokes epileptic seizures. Side effects and here in the use of drugs: a sense of fatigue, muscle weakness, a violation of coordination, dizziness, ataxia, hypersensitivity to light, reduced concentration, sleep disturbance, confusion, violation orientation, retrograde amnesia, behavioral disorders, depression can be enhanced with increasing doses of the drug; long-term therapy or treatment with high doses - negotiable unclear and it slowed, weakening of motor coordination, disorder in the form of double vision and nystagmus, dyspeptic symptoms, abnormal liver function tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation violation, decreased libido, impotence, premature emergence secondary sexual characteristics (in exceptional cases), urinary incontinence, depression of respiratory center (while application of other drugs that are inhibitory to respiratory Hysterosalpingogram AR - symptoms of hypersensitivity - angioedema, anaphylactic symptoms (in exceptional cases), the use of benzodiazepines may cause occurrence narcissus both mental and physical drug Mean Cell Volume of dependence associated with the dose and duration treatment are particularly susceptible to this condition patients with a history of alcohol dependence or other illness; sharp cessation of treatment after prolonged klonazepamom narcissus use can cause withdrawal with-m - the fear, increased sweating, motor agitation, anxiety, sleep disorders, head and muscle narcissus increased tension, Feeling narcissus violation of orientation, irritability, there is the danger of attack by the court or narcissus seizures, in extreme cases, narcissus have a sense of reality Nerve Conduction Velocity perception of their own personality, sensitivity to light, sound and touch, paresthesias of extremities, hallucinations, withdrawal symptoms of c-m usually occur in cases of sudden stopping treatment, so discontinuation of the drug should gradually reduce the dose, paradoxical reactions may occur - Psychomotor agitation, insomnia. Indications for use drugs: treatment of primary sleep disorders: sleep difficult, night and awakened early, transient situational and XP. Method of production of drugs: Table.-Coated, scored, 5 mg, 10 mg. hr. Side effects and complications in the use of drugs: mild bitter or metallic taste in the mouth, occasionally found gastrointestinal (nausea, vomiting) and mental disorders (irritability, confusion, depressed mood); allergic manifestations (nettles `Janko, rash), with the narcissus may be marked drowsiness, occasionally - and dizziness violation coordination of movement. Holinoblokator central.
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